EHMTI-0047. Genetic association and gene expression studies suggest that genetic variants in the SYNE1 and TNF genes are related to menstrual migraine
نویسندگان
چکیده
Methods Migraine diagnosis was in accordance with ICHD-II. Diagnosis of pure menstrual migraine and menstrually-related migraine was confirmed by diary evidence from at least three menstrual cycles. Controls were women with no personal or family history of migraine, age and ethnicity matched to cases, where possible. A total of 37 variants distributed across14 genes were genotyped in 437 DNA samples (282 cases and 155 controls [median age 45.0 vs. 39.5 years]). In addition levels of gene expression were determined in 74 cDNA samples (41 cases and 33 controls [median age 42.0 vs. 35.5 years]). Association and correlation analysis were performed using Plink and RStudio.
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